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The crash happened on eastbound Veterans Memorial Highway at Lakeland Avenue in Ronkonkoma at about 11:50 a.m. on Wednesday, Dec. 29, according to the Suffolk County Police Department.
A 48-year-old Holtsville man was driving a 2015 Honda when he collided with a 2019 Honda at the intersection.
Police said the man's vehicle then struck a 2010 Jeep in the left turning lane, which caused a chain reaction involving at least two additional vehicles that were also in the turning lane.
The 48-year-old was hospitalized with serious injuries, authorities said.
No other injuries were reported at the scene, police said.
The two Hondas, the Jeep, a 2010 Kia and a 2019 Nissan were impounded for safety checks, police reported.
Investigators asked anyone with information about the crash to call police at 631-854-8552.
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